We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Impaired endothelium‐dependent vasodilatation in uraemia.
- Authors
Morris, Scott T. W.; McMurray, John J. V.; Rodger, R. Stuart C.; Jardine, Alan G.
- Abstract
Background. Patients with chronic renal failure (CRF) have a substantially increased risk of cardiovascular death, the proposed mechanisms being arrhythmias (left ventricular hypertrophy) and accelerated atherosclerosis. The vascular endothelium protects against the development of atherosclerosis principally by releasing vasoactive substances such as nitric oxide (NO) and endothelium‐derived hyperpolarizing factor. In CRF there is accumulation of endogenous inhibitors of NO synthesis. In this present study we assessed endothelium‐dependent vasodilatation in patients with advanced uraemia.
- Publication
Nephrology Dialysis Transplantation, 2000, Vol 15, Issue 8, p1194
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/15.8.1194