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- Title
Aluminium Uptake by Intestinal Cells: Effect of Iron Status and Precomplexation.
- Authors
Fernández Menéndez, M. J.; Fell, G. S.; Brock, J. H.; Cannata, J. B.
- Abstract
The investigation of different aluminiumbinding agents and metabolic conditions that might act as critical factors in modulating aluminium absorption could yield valuable information in the understanding of aluminium gastrointestinal absorption. We evaluated the effect of iron depletion in aluminium uptake and the role of transferrin and citrate in aluminium incorporation by the intestinal epithelial cell line RIE1. Both complex, aluminium-citrate and aluminium-transferrin were prepared in a molar ratio of 2:1; both facilitated the aluminium uptake although a greater aluminium incorporation was found when aluminium was administered as aluminium-transferrin. This difference became even greater in the iron-depleted cells (normal cells vs iron-depleted cells): 7.7±1.4 versus 30±5.6 ng Al/μg DNA (P<0.05). From these and previous data it is possible to speculate that iron status could modulate the intestinal uptake of aluminium and that both transferrin and citrate would act as effective carriers in the incorporation of aluminium into mucosal cells.
- Publication
Nephrology Dialysis Transplantation, 1991, Vol 6, Issue 9, p672
- ISSN
0931-0509
- Publication type
Article