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- Title
Interstitial fluid concentrations of aminoglycosides.
- Authors
Dan, Michael; Halkin, Hillel; Rubinstein, Ethan; Dan, M; Halkin, H; Rubinstein, E
- Abstract
Blood and interstitial fluid (I.F.) concentrations of gentamicin, tobramycin, netilmicin, sissomicin, kanamycin and amikacin were determined in rats following a single intramuscular injection. I.F. was sampled by the short term implantation of dialysis tubing containing paper discs. For the six agents tested blood and I.F. concentrations were similar. I.F. half lives of tobramycin, sissomicin, netilmicin and amikacin were longer than the corresponding blood half lives. For all agents the area under the time concentration curve (= AUC) in the I.F. was larger than the simultaneous blood AUC, suggesting an influx of the drug to the I.F. from a compartment different from the intravascular space. I.F. obtained from muscle tissue had identical drug concentrations to the I.F. obtained from the subcutaneous space. I.F. obtained from an implanted ‘tissue cage’ was significantly lower than I.F. obtained simultaneously by the dialysis technique. Our results suggest that aminoglycoside concentrations in the I.F. are similar to those observed in the blood. The technique used may be appropriate for pharmacokinetic studies of other antibiotics.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1981, Vol 7, Issue 5, p551
- ISSN
0305-7453
- Publication type
journal article