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- Title
Microglial cell origin and phenotypes in health and disease.
- Authors
Saijo, Kaoru; Glass, Christopher K.
- Abstract
Microglia - resident myeloid-lineage cells in the brain and the spinal cord parenchyma - function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of infection and injury, and participate in both innate and adaptive immune responses in the central nervous system. Microglia can become activated and/or dysregulated in the context of neurodegenerative disease and cancer, and thereby contribute to disease severity. Here, we discuss recent studies that provide new insights into the origin and phenotypes of microglia in health and disease.
- Subjects
NEUROGLIA; MICROGLIA; HOMEOSTASIS; NEURODEGENERATION; PHENOTYPES; PHYSIOLOGY; CELL metabolism; BRAIN metabolism; BRAIN; SPINAL cord; CELL differentiation; GENE expression; CELLS; TUMORS
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 11, p775
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3086