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- Title
The precursors of memory: models and controversies.
- Authors
Ahmed, Rafi; Bevan, Michael J.; Reiner, Steven L.; Fearon, Douglas T.
- Abstract
The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.
- Subjects
LYMPHOCYTES; IMMUNOLOGY; DEVELOPMENTAL biology; IMMUNE system; ONTOGENY; T cells
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 9, p662
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2619