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- Title
Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations.
- Authors
Zhang, Junhang; Gong, Chen; Yang, Zihan; Wei, Fan; Sun, Xin; Ji, Jie; Zeng, Yushun; Chang, Chi-feng; Liu, Xunan; Nair, Deepthi S. Rajendran; Thomas, Biju B.; Zhou, Qifa
- Abstract
Functional ultrasound (fUS) flow imaging provides a non-invasive method for the in vivo study of cerebral blood flow and neural activity. This study used functional flow imaging to investigate rat brain's response to ultrasound and colored-light stimuli. Male Long-Evan rats were exposed to direct full-field strobe flashes light and ultrasound stimulation to their retinas, while brain activity was measured using high-frequency ultrasound imaging. Our study found that light stimuli, particularly blue light, elicited strong responses in the visual cortex and lateral geniculate nucleus (LGN), as evidenced by changes in cerebral blood volume (CBV). In contrast, ultrasound stimulation elicited responses undetectable with fUS flow imaging, although these were observable when directly measuring the brain's electrical signals. These findings suggest that fUS flow imaging can effectively differentiate neural responses to visual stimuli, with potential applications in understanding visual processing and developing new diagnostic tools.
- Subjects
ULTRASONIC imaging; LATERAL geniculate body; DIAGNOSTIC imaging; ELECTRIC stimulation; CEREBRAL circulation; DEEP brain stimulation; BLOOD volume; MICROBUBBLE diagnosis; MICROBUBBLES
- Publication
Bioengineering (Basel), 2024, Vol 11, Issue 2, p174
- ISSN
2306-5354
- Publication type
Article
- DOI
10.3390/bioengineering11020174