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- Title
Statinele și efectul diabetogen (I).
- Authors
Bacinschi, Nicolae; Guțu, Ina; Caracaș, Anastasia; Latuș, Svetlana; BacinschiGheorghiță, Stela; Bacinschi, Aurelia; Ștîrba, Dumitru; Malancea, Olesea
- Abstract
Statins constitute the first-line medication in the primary and secondary prevention of cardiovascular accidents in patients with hypercholesterolemia, reducing by 25-30% the risk of myocardial infarction, ischemic stroke and cardiovascular lethality. Clinical studies over the past 10-15 years have demonstrated the likelihood of developing de novo diabetes after statin use. From these considerations, a series of problems are addressed, such as: Is the diabetogenic effect specific to the class of statins?; Does it depend on the dose used?; What is the benefit/risk ratio?; Which patients are more prone to developing diabetes?; what are the mechanisms of diabetes development?; Are there needed or developed diabetes prevention strategies for statin treatment?; Is it necessary to change the tactics of using statins in the development of diabetes?
- Subjects
STATINS (Cardiovascular agents); ISCHEMIC stroke; MYOCARDIAL infarction; ACCIDENT prevention; SECONDARY prevention
- Publication
Farmacist.ro, 2022, Issue 4, p16
- ISSN
1584-6539
- Publication type
Article