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- Title
Genetic influences on insulinemia in normotensive twins.
- Authors
Narkiewicz, Kryzstof; Chrostowska, Marzena; Kuchta, Grzegorz; Szczęch, Radosław; Welz, Anna; Rynkiewicz, Andrzej; Łysiak-Szydłowska, Wiesława; Pawłowski, Ryszard; Krupa-Wojciechowska, Barbara
- Abstract
The aim of this study was to establish the contribution of genetic factors to the variance of plasma insulin concentration in healty, normotensive twins. Seventeen pairs of monozygotic (MZ) and 17 pairs of dizygotic (DZ) twins were investigated. The test of genetic variance revealed a significantly larger within-pair variance of fasting plasma insulin (FPI) and a relative insulin resistance (RIR) in the DZ twins, in comparison with the MZ twins. Both FPI and RIR had a higher intraclass correlation coefficient in the MZ twins than in the DZ twins; the corresponding heritability estimates were 0.54 for FPI and 0.66 for RIR. Adjusting for age, gender, and body mass index did not affect heritability estimates for either FPI or RIR. Our data indicate that genetic factors are important determinants of insulinemia in normal subjects, independent of body mass index.
- Publication
American Journal of Hypertension, 1997, Vol 10, p467
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(97)90532-X