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- Title
Transforming growth factor-β1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines.
- Authors
Helseth, Eirik; Dalen, Are; Unsgaard, Geirmund; Skandsen, Toril; GrØNdahl-Hansen, Jan; Lund, Leif R.
- Abstract
Transforming growth factor-β1 has been shown to suppress the urokinase activity in the glioblastoma cell line T-MG1 and the carcinoma cell line T-CAR1. The molecular mechanisms behind the decrease in the proteolyic activity is shown to be at least partly due to increased synthesis of plasminogen activator inhibitor type-1 and not by decreased synthesis of urokinase.
- Publication
APMIS, 1988, Vol 96, Issue 7-12, p845
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1988.tb00952.x