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- Title
Synthesis of BuNENA in a continuous flow microreactor.
- Authors
Jiang, Zhi-Yuan; Hou, Jing; Zhan, Le-Wu; Li, Bin-Dong
- Abstract
In order to improve process safety, product purity, and production efficiency in the synthesis of N-n-butyl-N-(2-nitroxy-ethyl)nitramine (BuNENA), a two-stage continuous flow microreactor system was constructed by sequentially connecting the self-designed heart-shaped channel microreactor and the caterpillar microreactor. n-Butylethanolamine was used as the raw material, nitric acid and acetic anhydride were used as the nitrating agents. The results showed that when the flow rate of n-butylethanolamine was 1.00 mL.min− 1, the temperature of the heart-shaped channel microreactor was 10 ℃, the temperature of the caterpillar microreactor was 35 ℃, the molar ratio of ZnCl2 to n-butylethanolamine was 2%, the molar ratio of nitric acid to n-butylethanolamine was 2.4, and the molar ratio of ZnCl2 to n-butylethanolamine was 2.4, the result was best. Under the conditions, the reaction time was shortened to 300 s, the purity of BuNENA was up to 98.1%, and the yield was 87.1%.
- Subjects
ACETIC anhydride; NITRIC acid; ACETIC acid; ORDER picking systems; RAW materials; NUCLEAR reactors
- Publication
Journal of Flow Chemistry, 2023, Vol 13, Issue 4, p449
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-023-00287-9