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- Title
Continuous preparation for rifampicin.
- Authors
Li, Xin; Liu, Zhuang; Qi, Hao; Fang, Zheng; Huang, Siyu; Miao, Shanshan; Guo, Kai
- Abstract
To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.
- Subjects
CONTINUOUS flow reactors; RIFAMYCINS; AMYCOLATOPSIS mediterranei; POLYMERIZATION; CHEMICAL reactions
- Publication
Journal of Flow Chemistry, 2018, Vol 8, Issue 3/4, p129
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-018-0017-2