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- Title
CRRT 治疗剂量对脓毒症休克合并急性肾损伤患者免疫功能 及预后的影响.
- Authors
张红伟; 胡金涛; 徐放; 于占彪; 韩丹丹
- Abstract
Objective: To investigate the effect of continuous renal replacement therapy (CRRT) treatment dose on immune function and prognosis in patients with septic shock and acute kidney injury (AKI). Methods: 120 patients with septic shock and acute kidney injury (AKI) admitted to our hospital from March 2016 to December 2017 were randomly divided into high-dose group, middle-dose group, low-dose group and control group, with 30 cases in each group.The control group received routine treatment, while the small dose group was treated with 20 mL/kg CRRT. The medium dose group was treated with 35 mL/kg CRRT, while the high-dose group was treated with 60 mL/kg CRRT. The renal function, immune function index, acute Physiology and Chronic Health EvaluationⅡ (APACHE II) score and sequential organ failure assessment (SOFA) score were compared between the 4 groups before and after treatment. Results: After treatment, the renal function indexes blood urea nitrogen (BUN) and Serum creatinine (Scr), APACHE II score and SOFA score were significantly lower in each group (P<0.05). After treatment, BUN and Scr, APACHE II score and SOFA score of the high dose group were lower than the other three groups. BUN and Scr, APACHE II score and SOFA score in the middle dose group and the low dose group were lower than in the control group, and BUN and Scr in the low dose group were lower than those in the control group (P<0.05). After treatment, the immune function indexes CD3+, CD4+ percentage and CD4+/CD8+ ratio were significantly increased in each group (P<0.05). The ratio of CD3+, CD4+ percentage and CD4+/CD8+ ratio in the high-dose group were higher than that in the other three groups. The middle-dose group were higher than the low-dose group and the control group, and the low-dose group were higher than the control group. The difference was statistically significant (P<0.05). Conclusion: CRRT can significantly improve the renal function and immune function of patients with sepsis and acute kidney injury, which can contribute to the recovery of patients' condition, and the high-dose group is better than the middle-dose and the low-dose.
- Subjects
BLOOD urea nitrogen; ACUTE kidney failure; SEPTIC shock; CONTROL groups; SEPSIS
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 15, p2937
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.15.031