We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives.
- Authors
Yakantham, T.; Sreenivasulu, R.; Alluraiah, G.; Tej, M. B.; Ramesh Raju, R.
- Abstract
A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.
- Subjects
ISOXAZOLES; LUNG cancer; OVARIAN cancer; COLON cancer; CELL lines; BREAST cancer
- Publication
Russian Journal of General Chemistry, 2019, Vol 89, Issue 12, p2522
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363219120314