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- Title
Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N<sub>4</sub> Schiff Base Complexes.
- Authors
Naglah, A. M.; Al-Omar, M. A.; Kalmouch, A.; Gobouri, A. A.; Abdel-Hafez, S. H.; El-Megharbel, S. M.; Refat, M. S.
- Abstract
Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vis, 1H, and 13C NMR) data. Au(III) Ion is coordinated with the synthesized Schiff bases via four nitrogen atoms of the antipyrine and azomethine groups. Au(III) Complexes are electrolytes with three uncoordinated Cl− ions, and have a square planar geometry. Their morphology is characterized by SEM and TEM methods. Cytotoxic effect of the complexes is tested against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines.
- Subjects
SPECTROMETRY; SCHIFF bases; HEPATOCELLULAR carcinoma; CHEMICAL structure; CELL lines; BREAST cancer
- Publication
Russian Journal of General Chemistry, 2019, Vol 89, Issue 8, p1702
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363219080255