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- Title
PD-1/CTLA-4 Blockade Leads to Expansion of CD8<sup>+</sup>PD-1<sup>int</sup> TILs and Results in Tumor Remission in Experimental Liver Cancer.
- Authors
Bufe, Sandra; Zimmermann, Artur; Ravens, Sarina; Prinz, Immo; Buitrago-Molina, Laura Elisa; Geffers, Robert; Woller, Norman; Kühnel, Florian; Talbot, Steven R.; Noyan, Fatih; Manns, Michael Peter; Wedemeyer, Heiner; Hardtke-Wolenski, Matthias; Jaeckel, Elmar; Davalos-Misslitz, Ana C.
- Abstract
Transferred naïve CD8 SP + sp CD45.1 SP + sp HA-specific T cells behaved similar to endogenous CD8 SP + sp CD45.2 SP + sp T cells (Fig. (b) CD4, CD8, and FoxP3 and (d) CD8, CD44, and PD-1. e Representative staining for CD8, PD-1, and Ki67 14 and 21 days after tumor induction. f Quantitative analysis at the same time points. The fate of naive tumor-specific T cells (CD8 SP + sp CD45.1 SP + sp HA-specific T cells) adoptively transferred 10 days after tumor induction was also investigated. While effector CD8 SP + sp and CD4 SP + sp Foxp3 SP - sp T cells were found almost exclusively in the tumors of treated mice, CD4 SP + sp Foxp3 SP + sp regulatory T cells (Tregs) were present in the tumors of both mouse groups (Fig.
- Subjects
LIVER cancer; CYTOTOXIC T cells; BLOCKADE; REGULATORY T cells; T-cell exhaustion
- Publication
Liver Cancer (2235-1795), 2023, Vol 12, Issue 2, p1
- ISSN
2235-1795
- Publication type
Article
- DOI
10.1159/000526899