We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In Vitro and In Vivo Study of Ion-Implanted Collagen for the Substrate of Small Diameter Artificial Grafts.
- Authors
Kurotobi, Kimi; Suzuki, Yoshiaki; Kaibara, Makoto; Iwaki, Masaya; Nakajima, Hiroshi; Suzuki, Hidenori
- Abstract
Ion implantation into the collagen-coated inner surface of the grafts was performed and evaluated in vitro and in vivo to develop small diameter artificial vascular grafts. He+ ion implanted collagen-coated grafts with a fluence of 1 × 1014 ions/cm2 inhibited platelet adhesion and demonstrated patency for 240 days in an animal study. The platelet adhesion test using platelet rich plasma (PRP) showed antithrombogenicity at the fluence of 1 × 1014 ions/cm2 . Washed platelet adhesion test showed thrombus formation at the fluence of 1 × 1014 ions/cm2 . The results suggested that plasma protein adsorption onto the ion-implanted collagen significantly improved performance of these synthetic grafts.
- Subjects
VASCULAR grafts; ION implantation
- Publication
Artificial Organs, 2003, Vol 27, Issue 6, p582
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1046/j.1525-1594.2003.07016.x