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- Title
Upregulation of Presenilin 1 in Brains of Sporadic, Late-Onset Alzheimer's Disease.
- Authors
Borghi, Roberta; Piccini, Alessandra; Barini, Erica; Cirmena, Gabriella; Guglielmotto, Michela; Tamagno, Elena; Fornaro, Michele; Perry, George; Smith, Mark A.; Garuti, Anna; Tabaton, Massimo
- Abstract
The activity of the β-secretase involved in the cleavage of amyloid-β (Aβ) is increased in sporadic late-onset Alzheimer's disease (AD). Whether the corresponding γ-secretase activity is altered is still uncertain. We evaluated mRNA expression and protein levels of presenilin 1 (PS1) and γ-secretase activity in the frontal cortex of 32 cases with late-onset sporadic AD and those of 29 control subjects. We found a significant increase in PS1 mRNA, protein levels and γ-secretase activity in AD cases. These findings suggest that upregulation of PS1 leads to Aβ overproduction and accumulation in sporadic AD.
- Subjects
PRESENILINS; ALZHEIMER'S disease; AMYLOID beta-protein; MESSENGER RNA; BRAIN
- Publication
Journal of Alzheimer's Disease, 2010, Vol 22, Issue 3, p771
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-100729