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- Title
Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle.
- Authors
Zubarev, Dmitry Yu; Rappoport, Dmitrij; Aspuru-Guzik, Alán
- Abstract
We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended.
- Subjects
CATALYTIC activity; MAILLARD reaction; TRICARBOXYLIC acids; CHEMICAL amplification; COMBINATORIAL chemistry
- Publication
Scientific Reports, 2015, p8009
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep08009