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- Title
All Quiet on the TE Front? The Role of Chromatin in Transposable Element Silencing.
- Authors
Di Stefano, Luisa
- Abstract
Transposable elements (TEs) are mobile genetic elements that constitute a sizeable portion of many eukaryotic genomes. Through their mobility, they represent a major source of genetic variation, and their activation can cause genetic instability and has been linked to aging, cancer and neurodegenerative diseases. Accordingly, tight regulation of TE transcription is necessary for normal development. Chromatin is at the heart of TE regulation; however, we still lack a comprehensive understanding of the precise role of chromatin marks in TE silencing and how chromatin marks are established and maintained at TE loci. In this review, I discuss evidence documenting the contribution of chromatin-associated proteins and histone marks in TE regulation across different species with an emphasis on Drosophila and mammalian systems.
- Subjects
MOBILE genetic elements; HISTONES; CHROMATIN; EUKARYOTIC genomes; GENETIC variation; GENETIC transcription regulation
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 16, p2501
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11162501