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- Title
Cardiovascular Inflammaging: Mechanisms and Translational Aspects.
- Authors
Barcena, Maria Luisa; Aslam, Muhammad; Pozdniakova, Sofya; Norman, Kristina; Ladilov, Yury
- Abstract
Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.
- Subjects
CARDIOVASCULAR fitness; WEIGHT loss; TYPE 2 diabetes; CARDIOVASCULAR diseases; PHYSICAL activity; OXIDATIVE stress; AUTOPHAGY
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 6, p1010
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11061010