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- Title
Chronic Low Dose Morphine Does Not Alter Two In Vitro BBB Models.
- Authors
Marino, Jamie; Maubert, Monique E.; Lawrence, Jill M.; Wigdahl, Brian; Nonnemacher, Michael R.
- Abstract
The blood–brain barrier (BBB) mediates cellular and molecular passage between the central nervous system (CNS) and peripheral circulation. Compromised BBB integrity has been linked to neurocognitive deficits in multiple diseases and various infections, including those associated with HIV-1 infection. Understanding the impact of exposure to pharmaceuticals, such as those utilized for pain management by patients suffering from CNS disease, on BBB regulation and function is clinically important. In this study, we modelled two different BBB systems; a primary human co-culture and a cell line monoculture. These systems were both exposed to three daily repeat doses of morphine and examined for alterations to BBB integrity via permeability, PBMC transmigration, and chemokine gradient changes. We did not find any significant changes to either BBB system with repeat morphine dosing, suggesting that repeat morphine exposure may not play a significant role in BBB changes.
- Subjects
MORPHINE; CENTRAL nervous system; PERIPHERAL circulation; BLOOD-brain barrier; PAIN management
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 7, pN.PAG
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12070888