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- Title
Metabolomics applied to islet nutrient sensing mechanisms.
- Authors
Jensen, Mette V.; Gooding, Jessica R.; Ferdaoussi, Mourad; Dai, Xiao-Qing; Peterson, Brett S.; Macdonald, Patrick E.; Newgard, Christopher B.
- Abstract
After multiple decades of investigation, the precise mechanisms involved in fuel-stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of 'metabolomics,' involving mass spectrometry and nuclear magnetic resonance-based profiling of islet cells in their fuel-stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose-stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.
- Subjects
METABOLOMICS; ISLANDS of Langerhans; MASS spectrometry; NUCLEAR magnetic resonance; TYPE 1 diabetes; DIAGNOSIS; PHYSIOLOGY
- Publication
Diabetes, Obesity & Metabolism, 2017, Vol 19, p90
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.13010