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- Title
MGL_3741 gene contributes to pathogenicity of Malassezia globosa in pityriasis versicolor.
- Authors
Aghaei Gharehbolagh, Sanaz; Kordbacheh, Parivash; Hashemi, Seyed Jamal; Daie Ghazvini, Roshanak; Asgari, Yazdan; Agha Kuchak Afshari, Setareh; Seyedmousavi, Seyedmojtaba; Rezaie, Sassan
- Abstract
Summary: Dihydroxyacid dehydratase (DHAD) is a key enzyme in biosynthetic pathway of isoleucine and valine. This pathway is absent in human but exists in various organisms such as fungi. Using RNA‐seq analysis in this study, we identified MGL_3741gene which encodes DHAD protein in Malassezia globosa (M. globosa). Furthermore, we found that mentioned gene is homologous to the Ustilago maydis, Saccharomyces cerevisiae, Aspergillus flavus, and Aspergillus fumigatus ILV3P. For understanding the probable role of this gene in pathogenicity of M. globosa, we applied Real‐time PCR to investigate the differentially expressed of the MGL_3741 gene in healthy and pathogenic states. Our results indicate a significant difference between two mentioned stats. These results revealed that ILV3‐like gene in M. globosa can be related to the pathogenicity of this yeast.
- Subjects
ISOLEUCINE; SACCHAROMYCES cerevisiae; ASPERGILLUS fumigatus; USTILAGO maydis; MICROBIAL virulence
- Publication
Mycoses, 2018, Vol 61, Issue 12, p938
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12840