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- Title
Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis.
- Authors
Massarotti, Claudia; Sbragia, Elvira; Boffa, Giacomo; Vercelli, Caterina; Zimatore, Giovanni Bosco; Cottone, Salvatore; Frau, Jessica; Raiola, Annamaria; Varaldo, Riccardo; Mancardi, Gianluigi; Inglese, Matilde; Anserini, Paola
- Abstract
Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens' intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.
- Subjects
HEMATOPOIETIC stem cell transplantation; MENSTRUAL cycle; FERTILITY; MULTIPLE sclerosis; HUMAN fertility
- Publication
Multiple Sclerosis Journal, 2021, Vol 27, Issue 13, p2103
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211000616