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- Title
Age-Period-Cohort Analysis of Thyroid Cancer Incidence in Korea.
- Authors
Chang-Mo Oh; Kyu-Won Jung; Young-Joo Won; Aesun Shin; Hyun-Joo Kong; Jin-Soo Lee
- Abstract
Purpose: South Korea has the highest incidence rate of thyroid cancer in the world, and the incidence rate continues to increase. The aim of this study was to determine the age-period-cohort effects on the incidence of thyroid cancer in Korea. Materials and Methods: Using the Korean National Cancer registry database, age-standardized incidence rates and annual percent changes (APCs) in thyroid cancer according to sex and histologic type were analyzed between 1997 and 2011. Age-period-cohort models were applied using an intrinsic estimator method according to sex. Results: In both men and women, the incidence of thyroid cancer showed a sharp increase from 1997 through 2011. Among the histologic types, papillary carcinoma showed the greatest increase, with APCs of 25.1% (95% confidence interval [CI], 22.7% to 27.5%) in men and 23.7% (95% CI, 21.9% to 25.5%) in women, whereas anaplastic carcinoma did not show a significant increase in either sex. An increase in overall thyroid cancer incidence over time was observed in all birth cohorts. An age-period-cohort model indicated a steeply increasing period effect, which increased prominently from 1997 to 2011 in both men and women. The age effect showed an inverted U-shaped trend. The cohort effect tended to show a slight increase or remain constant from 1952 to 1977, followed by a decrease. Conclusion: The period effect can explain the sharp increase in thyroid cancer incidence, strongly suggesting the role of thyroid screening.
- Subjects
SOUTH Korea; THYROID cancer; EPIDEMIOLOGY of cancer; THYROID cancer treatment; PUBLIC health; COHORT analysis
- Publication
Cancer Research & Treatment, 2015, Vol 47, Issue 3, p362
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2014.110