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- Title
miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing.
- Authors
He, Wen-Zhen; Yang, Mi; Jiang, Yangzi; He, Chen; Sun, Yu-Chen; Liu, Ling; Huang, Mei; Jiao, Yu-Rui; Chen, Kai-Xuan; Hou, Jing; Huang, Min; Xu, Yi-Li; Feng, Xu; Liu, Ya; Guo, Qi; Peng, Hui; Huang, Yan; Su, Tian; Xiao, Ye; Li, Yusheng
- Abstract
A specific bone capillary subtype, namely type H vessels, with high expression of CD31 and endomucin, was shown to couple angiogenesis and osteogenesis recently. The number of type H vessels in bone tissue declines with age, and the underlying mechanism for this reduction is unclear. Here, we report that microRNA-188-3p (miR-188-3p) involves this process. miRNA-188-3p expression is upregulated in skeletal endothelium and negatively regulates the formation of type H vessels during ageing. Mice with depletion of miR-188 showed an alleviated age-related decline in type H vessels. In contrast, endothelial-specific overexpression of miR-188-3p reduced the number of type H vessels, leading to decreased bone mass and delayed bone regeneration. Mechanistically, we found that miR-188 inhibits type H vessel formation by directly targeting integrin β3 in endothelial cells. Our findings indicate that miR-188-3p is a key regulator of type H vessel formation and may be a potential therapeutic target for preventing bone loss and accelerating bone regeneration.
- Publication
Cell Death & Disease, 2022, Vol 13, Issue 5, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-022-04902-w