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- Title
Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis.
- Authors
Xu, Yan; Xue, Meilan; Li, Jing; Ma, Yiqing; Wang, Yutong; Zhang, Huaqi; Liang, Hui
- Abstract
Recent studies have indicated that fucoidan has the potential to improve cognitive impairment. The objective of this study was to demonstrate the protective effect and possible mechanisms of fucoidan in D-galactose (D-gal)-induced cognitive dysfunction. Sprague Dawley rats were injected with D-galactose (200 mg/kg, sc) and administrated with fucoidan (100 mg/kg or 200 mg/kg, ig) for 8 weeks. Our results suggested that fucoidan significantly ameliorated cognitive impairment in D-gal-exposed rats and reversed histopathological changes in the hippocampus. Fucoidan reduced D-gal-induced oxidative stress, declined the inflammation level and improved mitochondrial dysfunction in hippocampal. Fucoidan promoted mitochondrial biogenesis by regulating the PGC-1α/NRF1/TFAM pathway, thereby improving D-gal-induced mitochondrial dysfunction. The regulation effect of fucoidan on PGC-1α is linked to the upstream protein of APN/AMPK/SIRT1. Additionally, the neuroprotective action of fucoidan could be related to maintaining intestinal flora homeostasis with up-regulation of Bacteroidota, Muribaculaceae and Akkermansia and down-regulation of Firmicutes. In summary, fucoidan may be a natural, promising candidate active ingredient for age-related cognitive impairment interventions.
- Subjects
INFLAMMATION prevention; NEUROPROTECTIVE agents; HOMEOSTASIS; RESEARCH funding; CELL physiology; GUT microbiome; HEXOSES; OXIDATIVE stress; CELLULAR signal transduction; POLYSACCHARIDES; RATS; COGNITION disorders; ANIMAL experimentation; MITOCHONDRIAL pathology; HIPPOCAMPUS (Brain)
- Publication
Nutrients, 2024, Vol 16, Issue 10, p1512
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16101512