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- Title
Improvement of Cognitive Function by Fermented Panax ginseng C.A. Meyer Berries Extracts in an AF64A-Induced Memory Deficit Model.
- Authors
Yoon, Eun-Jung; Ahn, Jeong-Won; Kim, Hyun-Soo; Choi, Yunseo; Jeong, Jiwon; Joo, Seong-Soo; Park, Dongsun
- Abstract
This study investigated the potential therapeutic properties of fermented ginseng berry extract (GBE) for Alzheimer's disease (AD). Fermented GBE was examined for its ginsenoside content and physiological properties, which have been suggested to have neuroprotective effects and improve cognitive function. The results showed that fermented GBE contains high levels of major active ginsenosides and exhibits antioxidant and acetylcholinesterase inhibitory activities. Post-fermented GBE demonstrated therapeutic potential in AF64A-induced damaged neural stem cells and an animal model of AD. These findings suggest that fermented GBE may hold promise as a candidate for developing new therapeutic interventions for memory deficits and cognitive disorders associated with AD and other neurodegenerative conditions. However, further studies are needed to evaluate the safety, tolerability, and efficacy of fermented GBE in human subjects and to determine its clinical applications. In conclusion, our study provides evidence that fermented GBE has potential as a natural product for the prevention and treatment of AD. The high levels of active ginsenosides and antioxidant and acetylcholinesterase inhibitory activities of fermented GBE suggest that it may be a promising therapeutic agent for improving cognitive function and reducing neurodegeneration.
- Subjects
ALZHEIMER'S disease prevention; BIOTHERAPY; THERAPEUTIC use of ginseng; COGNITION disorders; BIOLOGICAL models; ACETYLCHOLINESTERASE; RODENTS; MEDICINAL plants; ALZHEIMER'S disease; FUNCTIONAL status; ANIMAL experimentation; GLYCOSIDES; MEMORY disorders; NEUROPROTECTIVE agents; RESEARCH funding; DESCRIPTIVE statistics; PLANT extracts; BERRIES; DATA analysis software; GINSENG; FERMENTATION; NEURODEGENERATION
- Publication
Nutrients, 2023, Vol 15, Issue 15, p3389
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15153389