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- Title
Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice.
- Authors
Velankanni, Priyanka; Go, Seok-Ho; Jin, Jong Beom; Park, Jin-Soo; Park, Sunhee; Lee, Su-Bin; Kwon, Ho-Keun; Pan, Cheol-Ho; Cha, Kwang Hyun; Lee, Choong-Gu
- Abstract
Chlorella vulgaris (C. vulgaris) is unicellular green algae consumed worldwide as a functional food. The immune stimulatory function of C. vulgaris is known; however, no study has elucidated its immune regulatory potential and associated microbiome modulation. In the current study, we aimed to validate the immune regulatory role of C. vulgaris mediated through two mechanisms. Initially, we assessed its ability to promote the expansion of the regulatory T cell (Treg) population. Subsequently, we investigated its impact on gut microbiota composition and associated metabolites. The supplementation of C. vulgaris altered the gut microbiota composition, accompanied by increased short-chain fatty acid (SCFAs) production in mice at homeostasis. We later used C. vulgaris in the treatment of a DSS-induced colitis model. C. vulgaris intervention alleviated the pathological symptom of colitis in mice, with a corresponding increase in Treg levels. As C. vulgaris is a safe and widely used food supplement, it can be a feasible strategy to instigate cross-talk between the host immune system and the intestinal flora for the effective management of inflammatory bowel disease (IBD).
- Subjects
COLITIS prevention; HOMEOSTASIS; GUT microbiome; ANIMAL experimentation; IMMUNE system; REGULATORY T cells; DIETARY supplements; DESCRIPTIVE statistics; RESEARCH funding; ALGAE; COLITIS; MICE; METABOLITES; SHORT-chain fatty acids
- Publication
Nutrients, 2023, Vol 15, Issue 15, p3293
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15153293