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- Title
Effects of Genistein on Common Kidney Diseases.
- Authors
Peng, Qianwen; Li, Yuanyuan; Shang, Jia; Huang, Haitao; Zhang, Yiming; Ding, Yueming; Liang, Yipei; Xie, Zhenxing; Chen, Chaoran
- Abstract
Genistein is a naturally occurring phytoestrogen (soy or soybean products) that is classified as an isoflavone, and its structure is similar to that of endogenous estrogens; therefore, genistein can exert an estrogen-like effect via estrogen receptors. Additionally, genistein is a tyrosine kinase inhibitor, which enables it to block abnormal cell growth and proliferation signals through the inhibition of tyrosine kinase. Genistein is also an angiogenesis inhibitor and an antioxidant. Genistein has effects on kidney cells, some of the kidney's physiological functions, and a variety of kidney diseases. First, genistein exerts a protective effect on normal cells by reducing the inflammatory response, inhibiting apoptosis, inhibiting oxidative stress, inhibiting remodeling, etc., but after cell injury, the protective effect of genistein decreases or even has the opposite effect. Second, genistein can regulate renin intake to maintain blood pressure balance, regulate calcium uptake to regulate Ca2+ and Pi balances, and reduce vasodilation to promote diuresis. Third, genistein has beneficial effects on a variety of kidney diseases (including acute kidney disease, kidney cancer, and different chronic kidney diseases), such as reducing symptoms, delaying disease progression, and improving prognosis. Therefore, this paper reviews animal and human studies on the protective effects of genistein on the kidney in vivo and in vitro to provide a reference for clinical research in the future.
- Subjects
INFLAMMATION prevention; ACUTE kidney failure prevention; KIDNEY disease prevention; DISEASE progression; ENDOTHELIAL cells; KIDNEYS; NEOVASCULARIZATION inhibitors; ANTI-inflammatory agents; ANTIOXIDANTS; APOPTOSIS; RENIN-angiotensin system; PROTEIN-tyrosine kinase inhibitors; KIDNEY diseases; OXIDATIVE stress; VASODILATION; GENISTEIN; DIURESIS; KIDNEY tumors; CELL proliferation
- Publication
Nutrients, 2022, Vol 14, Issue 18, pN.PAG
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14183768