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- Title
Anti-Diabetic Effects of Allulose in Diet-Induced Obese Mice via Regulation of mRNA Expression and Alteration of the Microbiome Composition.
- Authors
Han, Youngji; Kwon, Eun-Young; Choi, Myung-Sook
- Abstract
Allulose has been reported to serve as an anti-obesity and anti-diabetic food component; however, its molecular mechanism is not yet completely understood. This study aims to elucidate the mechanisms of action for allulose in obesity-induced type 2 diabetes mellitus (T2DM), by analyzing the transcriptional and microbial populations of diet-induced obese mice. Thirty-six C57BL/6J mice were divided into four groups, fed with a normal diet (ND), a high-fat diet (HFD), a HFD supplemented with 5% erythritol, or a HFD supplemented with 5% allulose for 16 weeks, in a pair-fed manner. The allulose supplement reduced obesity and comorbidities, including inflammation and hepatic steatosis, and changed the microbial community in HFD-induced obese mice. Allulose attenuated obesity-mediated inflammation, by downregulating mRNA levels of inflammatory response components in the liver, leads to decreased plasma pro-inflammatory marker levels. Allulose suppressed glucose and lipid metabolism-regulating enzyme activities, ameliorating hepatic steatosis and improving dyslipidemia. Allulose improved fasting blood glucose (FBG), plasma glucose, homeostatic model assessment of insulin resistance (HOMA-IR), and the area under the curve (AUC) for the intraperitoneal glucose tolerance test (IPGTT), as well as hepatic lipid levels. Our findings suggested that allulose reduced HFD-induced obesity and improved T2DM by altering mRNA expression and the microbiome community.
- Subjects
DRUG therapy for hyperlipidemia; ANIMAL experimentation; BIOLOGICAL models; BLOOD sugar; HUMAN microbiota; GENE expression; HYPOGLYCEMIC agents; INFLAMMATION; MESSENGER RNA; MICE; MONOSACCHARIDES; TYPE 2 diabetes; OBESITY; SWEETENERS; PHARMACODYNAMICS
- Publication
Nutrients, 2020, Vol 12, Issue 7, p2113
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12072113