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- Title
Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria.
- Authors
Hanson, Corrine; Lyden, Elizabeth; Anderson-Berry, Ann; Kocmich, Nicholas; Rezac, Amy; Delair, Shirley; Van Ormer, Matthew; Obaro, Stephen; Furtado, Jeremy; Izevbigie, NI; Olateju, EK; Adaba, GA; Anigilaje, EA; Tahiru, Tahiru
- Abstract
Vitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.
- Subjects
NIGERIA; APGAR score; BLOOD testing; CAROTENOIDS; DIETARY supplements; CORD blood; HIGH performance liquid chromatography; LYCOPENE; REGRESSION analysis; RETINOIDS; STATISTICS; VITAMIN A; DATA analysis; BETA carotene; DESCRIPTIVE statistics; CRYPTOXANTHIN; ZEAXANTHIN; LUTEIN; MANN Whitney U Test
- Publication
Nutrients, 2018, Vol 10, Issue 9, p1286
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10091286