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- Title
Changes in the Anti-Allergic Activities of Sesame by Bioconversion.
- Authors
Jung, Tae-Dong; Choi, Sun-Il; Choi, Seung-Hyun; Cho, Bong-Yeon; Sim, Wan-Sup; Xionggao, Han-; Lee, Sang Jong; Park, Seon Ju; Kim, Dan-Bi; Kim, Young-Cheul; Lee, Jin-Ha; Lee, Ok-Hwan
- Abstract
Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1 β (IL-1β), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-kκB and STAT1 activation.
- Subjects
ALLERGENS; ANTIGENS; BIOTRANSFORMATION (Metabolism); CARRIER proteins; CELL adhesion molecules; CELL lines; CHEMOKINES; CYTOKINES; ELECTROPHORESIS; FERMENTATION; GENE expression; INTERFERONS; INTERLEUKINS; PROTEINS; THYMUS; TRANSCRIPTION factors; TUMOR necrosis factors; DNA-binding proteins; PLANT extracts
- Publication
Nutrients, 2018, Vol 10, Issue 2, p210
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10020210