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- Title
Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and antiinflammatory mechanisms.
- Authors
Pin-Kuei Fu; Tai-Long Pan; Chi-Yu Yang; Kee-Ching Jeng; Nou-Ying Tang; Ching-Liang Hsieh
- Abstract
Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period. The cerebral infarction area, neurological deficit scores, free radicals (lucigenin chemiluminescence counts) and pro-inflammatory cytokines expression were measured. Results: Pretreatment and treatment with CTE significantly reduced the cerebral infarction area and neurological deficits. CTE (0.4 g/kg) also reduced blood levels of free radicals and expression of tumor necrosis factor-α and interleukin-1β in the cerebral infarction area. Conclusion: The reduction in I/R cerebral infarction caused by CTE is possibly associated with its antioxidation and anti-inflammatory properties.
- Subjects
SAFFLOWER; BRAIN injuries; CEREBRAL ischemia; REPERFUSION; ANTI-inflammatory agents
- Publication
Iranian Journal of Basic Medical Sciences, 2016, Vol 19, Issue 12, p1368
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/ijbms.2016.7925