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- Title
Ultrasmall particles for Gd-MRI and <sup>68</sup>Ga-PET dual imaging.
- Authors
Truillet, Charles; Bouziotis, Penelope; Tsoukalas, Charalambos; Brugière, Jérémy; Martini, Matteo; Sancey, Lucie; Brichart, Thomas; Denat, Franck; Boschetti, Frédéric; Darbost, Ulrich; Bonnamour, Isabelle; Stellas, Dimitris; Anagnostopoulos, Constantinos D.; Koutoulidis, Vassilis; Moulopoulos, Lia A.; Perriat, Pascal; Lux, François; Tillement, Olivier
- Abstract
Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd3+] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[68Ga3+] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after 68Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.Copyright © 2014 John Wiley & Sons, Ltd.
- Publication
Contrast Media & Molecular Imaging, 2015, Vol 10, Issue 4, p309
- ISSN
1555-4309
- Publication type
Article
- DOI
10.1002/cmmi.1633