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- Title
Role of pretransplant anti‐thymocyte globulin in matched sibling donor stem cell transplantation after reduced intensity conditioning for myelodysplastic syndrome.
- Authors
Yahng, Seung‐Ah; Min, Gi‐June; Park, Sung‐Soo; Park, Silvia; Jeon, Young‐Woo; Yoon, Jae‐Ho; Shin, Seung‐Hwan; Lee, Sung‐Eun; Cho, Byung‐Sik; Eom, Ki‐Seong; Lee, Seok; Min, Chang‐Ki; Kim, Hee‐Je; Lee, Jong‐Wook; Kim, Yoo‐Jin
- Abstract
Objective: We investigated the role of anti‐thymocyte globulin (ATG; Thymoglobulin) in matched sibling donor hematopoietic stem cell transplantation (MSD‐HSCT) after reduced intensity conditioning (RIC) in myelodysplastic syndrome (MDS). Methods: Forty‐seven patients with 10 mg/kg ATG (ATG group; median age 53 years) and 33 without ATG (no‐ATG group; median age 43, P <.0001) were compared. Results: Median time to engraftment was similar. Two‐year cumulative incidence of moderate‐to‐severe chronic graft‐versus‐host disease (GVHD) was significantly lower in the ATG group (15% vs 55%, P <.0001), while that of acute GVHD was similar compared with the no‐ATG group. After a median follow‐up of 60 months (range, 14‐184), the 3‐year cumulative incidences of non‐relapse mortality and relapse were 9% and 21% for ATG group and 15% and 19% for no‐ATG group (P =.408 and P =.717), respectively, leading to a significantly better 3‐year GVHD‐free and relapse‐free survival (GRFS) in the ATG group (55% vs 19%, P =.006): The 3‐year overall and disease‐free survival were similar. Infectious complication occurred with similar frequencies in both groups. Conclusion: These findings suggest that ATG can be safely used to decrease moderate‐to‐severe chronic GVHD with improved GRFS for patients with MDS receiving MSD‐HSCT in RIC setting.
- Subjects
STEM cell donors; MYELODYSPLASTIC syndromes; HEMATOPOIETIC stem cell transplantation; GLOBULINS; SIBLINGS; CANCER chemotherapy; CANCER radiotherapy
- Publication
European Journal of Haematology, 2020, Vol 104, Issue 5, p459
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13386