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- Title
Cisplatin and temozolomide combination in the treatment of leptomeningeal carcinomatosis from ethmoid sinus intestinal-type adenocarcinoma.
- Authors
Lombardi, Giuseppe; Zustovich, Fable; Della Puppa, Alessandro; Borgato, Lucia; Orvieto, Enrico; Manara, Renzo; Cecchin, Diego; Berti, Franco; Farina, Patrizia; Gardiman, Marina; Scienza, Renato; Zagonel, Vittorina
- Abstract
Intestinal-type adenocarcinoma of the nasal cavities and paranasal sinuses is a relatively rare tumor. Standard therapeutic modalities include surgery followed by radiotherapy, sometimes with chemotherapy treatment. Despite these treatments, the outcome is poor due to frequent local recurrences constituting the main cause of death among patients; leptomeningeal carcinomatosis is not a frequent event, and its presence indicates short expected survival. The therapy of neoplastic meningitis includes cranial irradiation, intrathecal chemotherapy and high-dose systemic chemotherapy. However, these approaches report important side effects with only modest efficacy. Thus, it is important to discover better treatment for this cancer complication. We present, for the first time, a case of leptomeningeal carcinomatosis from invasive intestinal-type adenocarcinoma treated with temozolomide and cisplatin chemotherapy obtaining a prolonged reduction and stabilization of the lesion improving the clinical condition of the patient.
- Subjects
PARANASAL sinuses; CANCER chemotherapy; CISPLATIN; NASAL tumors; MENINGEAL cancer; RARE diseases; DRUG side effects; COMBINATION drug therapy; TUMOR treatment
- Publication
Journal of Neuro-Oncology, 2011, Vol 104, Issue 1, p381
- ISSN
0167-594X
- Publication type
Report
- DOI
10.1007/s11060-010-0484-2