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- Title
Preparation and Characterization of Hydrogels Based on Dehydroabietyl Polyoxyethylene Glycidyl Ether Grafted Hydroxyethyl Chitosans and Their Capability for Loading and Controlled Release of Chloramphenicol.
- Authors
Xujuan Huang; Zhenqing Ding; Zhaosheng Cai; Ting Wang; Xinxin Yang; Shibin Shang
- Abstract
Dehydroabietol polyoxyethylene(10) ether (DHA(EO)10H) was reacted with epichlorohydrin (ECH) using BF3 as catalyst and transformed into DHA(EO)10H-ECH, then dehydrochlorinated in the presence of sodium hydroxide and converted into dehydroabietyl polyoxyethylene(10) glycidyl ether (DHA(EO)10GE). Hydroxyethyl chitosan (HEC) was modified with DHA(EO)10GE, and a series of different DHA(EO)10GE-grafted HECs (DHA(EO)10GE-g-HECs) were prepared. Finally, the hydrogels based on DHA(EO)10GE-g-HECs were obtained through the reaction between genipin (GE) and DHA(EO)10GE-g-HECs. Effects of the grafting degree (DG) of DHA(EO)10GE and the dosage of GE on the gelation ability of mixed solution composed of DHA(EO)10GE-g-HECs and GE were investigated, and the behaviors of DHA(EO)10GE-g-HEC/GE hydrogels as carriers for loading chloramphenicol (CAP) were studied. It was found that the gelling time of the DHA(EO)10GE-g-HEC with high DG was longer than that with low DG, and a higher GE dosage could improve the capability of DHA(EO)10GE-g-HEC to form hydrogels. The relation between the cumulative release rate of CAP, which was loaded in DHA(EO)10GE-g-HEC/GE gel, and the release times in artificial intestinal fluid could be well described by Boltzmann function. Increasing the DG or decreasing the GE dosage could improve the final cumulative release.
- Subjects
HYDROGELS; POLYETHYLENE glycol; CHLORAMPHENICOL; ETHERS; CAPITALIZATION rate; CHITOSAN
- Publication
BioResources, 2022, Vol 17, Issue 3, p4331
- ISSN
1930-2126
- Publication type
Article
- DOI
10.15376/biores.17.3.4331-4346