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- Title
Prediction of Drug-Resistant Epilepsy in Children With Cerebral Palsy.
- Authors
Tokatly Latzer, Itay; Blumovich, Amit; Sagi, Liora; Uliel-Sibony, Shimrit; Fattal-Valevski, Aviva
- Abstract
Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.
- Subjects
CHILDREN with cerebral palsy; CHILDHOOD epilepsy; CEREBRAL palsy; RECEIVER operating characteristic curves; LENNOX-Gastaut syndrome
- Publication
Journal of Child Neurology, 2020, Vol 35, Issue 3, p187
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073819883157