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- Title
Preparation of Enantiomerically Pure C<sub>4</sub>-Symmetric Tetramethoxyresorcarenes by Using the (-)-( S)-1-Phenylethyl Isocyanate Chiral Auxiliary.
- Authors
Thakar, Amit S.; Parekh, Hitesh M.; Pansuriya, Pramod B.; Friedrich, Holger B.; Maguire, Glenn E. M.
- Abstract
The synthesis of a series of tetramethoxyresorcarene diastereomers is reported. The reactions of inherently chiral C4-symmetric tetramethoxyresorcarene derivatives with the chiral auxiliary (-)-( S)-1-phenylethyl isocyanate gave new diastereomeric carbamate compounds in good yields. The diastereomers were separated by simple silica chromatography and then converted by hydrolysis into their parent tetramethoxyresorcarenes to yield the optically pure (-)-( M, R)- and (+)-( P, S) enantiomers.
- Subjects
RESORCINARENES; STYRENE; RESOLUTION (Chemistry); TIN research; CARBAMATES
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 21, p4600
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402125