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- Title
The Disubstitution of Acetals to Prepare δ,δ-Bis(aryl) β-Keto Esters.
- Authors
Priebbenow, Daniel L.; Zou, Liang‐Hua; Becker, Peter; Bolm, Carsten
- Abstract
An efficient catalytic protocol for the synthesis of δ,δ-bis(aryl)-substituted β-keto esters has been developed. This method involves the Lewis acid catalysed disubstitution reaction of ester-substituted silyl enol ether acetals with a series of aromatic nucleophiles to afford valuable functionalized β-keto esters with several sites available for further derivatisation.
- Subjects
ACETAL resins; KETONIC acids; ACID-base chemistry; ORGANIC compounds; NUCLEOPHILIC addition (Chemistry)
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 19, p3965
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300446