We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics.
- Authors
Kulikov, Oleg V.; Thompson, Sam; Xu, Hai; Incarvito, Christopher D.; Scott, Richard T. W.; Saraogi, Ishu; Nevola, Laura; Hamilton, Andrew D.
- Abstract
An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double α-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.
- Subjects
ALPHA helix structure (Proteins); PROTEIN analysis; AMINO acids; MEMBRANE proteins; X-rays; SINGLE crystals
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 17, p3433
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300363