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- Title
Evolution of a Synthetic Strategy for the Variecolortides.
- Authors
Kuttruff, Christian A.; Mayer, Peter; Trauner, Dirk
- Abstract
The variecolortides are a family of unusual natural products that combine motifs from a variety of biosynthetic streams. Herein, we present the gradual evolution of a convergent synthetic strategy that ultimately culminated in a reaction cascade featuring a hydrogen shift and a cycloaddition followed by a spontaneous air oxidation. Attempts to link an anthrone building block with an exo-methylene diketopiperazine using radical chemistry were ultimately unsuccessful, but led to interesting observations that shaped our successful strategy. The total synthesis of variecolortide C is presented for the first time.
- Publication
European Journal of Organic Chemistry, 2012, Vol 2012, Issue 27, p5151
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201200712