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Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells.
- Published in:
- BioMetals, 2021, v. 34, n. 2, p. 211, doi. 10.1007/s10534-020-00273-x
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- Article
A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway.
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- Journal of Cancer Research & Clinical Oncology, 2021, v. 147, n. 9, p. 2591, doi. 10.1007/s00432-021-03679-3
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- Article
Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative.
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- Journal of Cancer Research & Clinical Oncology, 2011, v. 137, n. 4, p. 639, doi. 10.1007/s00432-010-0924-6
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- Article
Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 2, p. 952, doi. 10.3390/ijms24020952
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- Article
Impact of A Six Week Training Program on Ventilatory Efficiency, Red Blood Cell Rheological Parameters and Red Blood Cell Nitric Oxide Signaling in Young Sickle Cell Anemia Patients: A Pilot Study.
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- Journal of Clinical Medicine, 2019, v. 8, n. 12, p. 2155, doi. 10.3390/jcm8122155
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- Article
Synthesis of Demethylxanthohumol, a New Potent Apoptosis-Inducing Agent from Hops.
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- Chemistry & Biodiversity, 2005, v. 2, n. 10, p. 1331, doi. 10.1002/cbdv.200590105
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- Article
Specialized pediatric palliative care services for children dying from cancer: A repeated cohort study on the developments of symptom management and quality of care over a 10-year period.
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- Palliative Medicine, 2019, v. 33, n. 3, p. 381, doi. 10.1177/0269216318818022
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- Publication type:
- Article
Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden.
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- Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0378-1
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- Article
Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden.
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- Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0378-1
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- Publication type:
- Article
Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden
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- Molecular Cancer, 2015, v. 14, n. 1, p. 114, doi. 10.1186/s12943-015-0378-1
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- Publication type:
- Article
Induction of apoptosis by enediyne antibiotic calicheamicin ?II proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner.
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- Oncogene, 2003, v. 22, n. 57, p. 9107, doi. 10.1038/sj.onc.1207196
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- Article
Biological Activity of Molybdenum(II) Allyl Dicarbonyl Complexes with N-N Coligands of Variable Aromatic Surface Area on Adherent and Non-adherent Human Cancer Cells.
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- Zeitschrift für Anorganische und Allgemeine Chemie, 2013, v. 639, n. 8/9, p. 1568, doi. 10.1002/zaac.201300055
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- Article
Unusual η<sup>2</sup>-Allene Osmacycle with Apoptotic Properties.
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- ChemBioChem, 2010, v. 11, n. 11, p. 1607, doi. 10.1002/cbic.201000055
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- Publication type:
- Article
Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48364-1
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- Article
Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.
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- Chemistry - A European Journal, 2017, v. 23, n. 8, p. 1869, doi. 10.1002/chem.201604512
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- Article
A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs.
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- Metallomics, 2019, v. 11, n. 3, p. 533, doi. 10.1039/c8mt00306h
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- Publication type:
- Article
Carbonyl-Substituted Titanocenes: A Novel Class of Cytostatic Compounds with High Antitumor and Antileukemic Activity.
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- Chemistry - A European Journal, 2008, v. 14, n. 14, p. 4160, doi. 10.1002/chem.200800407
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- Publication type:
- Article
Transition-Metal-Mediated Synthesis of Novel Carbocyclic Nucleoside Analogues with Antitumoral Activity.
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- Chemistry - A European Journal, 2004, v. 10, n. 20, p. 5087, doi. 10.1002/chem.200400079
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- Publication type:
- Article
Eisenhaltige Nucleosidanaloga mit apoptoseinduzierender Wirksamkeit ( Diese Arbeit wurde durch die Deutsche Forschungsgemeinschaft (Schm 875/1 H.G.S.), die Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS-R01/02; T.W. und A.P.), den Verein zur Förderung der Tagesklinik e.V. (A.P. und T.W.), die Berliner Krebsgesellschaft e.V. (T.W.) und den Fonds der Chemischen Industrie (H.G.S.) gefördert. Die Autoren danken Dr. P. T. Daniel für die freundliche Bereitstellung von BJAB-Zellen und von Laborausrüstung sowie Dr. J. Lex, Dr. H. Schmickler und Dr. M. Schäfer für röntgenkristallographische, NMR-spektroskopische und massenspektrometrische Messungen. A. Richter danken wir für die Unterstützung bei der Durchführung der Zell-Assays. )
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- Angewandte Chemie, 2004, v. 116, n. 13, p. 1763, doi. 10.1002/ange.200353132
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- Publication type:
- Article
Synthesis of Diverse 6-Oxa-allocolchicinoids by a Suzuki-Miyaura Coupling, Acid-Catalyzed Intramolecular Transacetalization Strategy.
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- European Journal of Organic Chemistry, 2015, v. 2015, n. 23, p. 5167, doi. 10.1002/ejoc.201500573
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- Article
Synthesis of Indole-Derived Allocolchicine Congeners through Pd-Catalyzed Intramolecular C-H Arylation Reaction.
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- European Journal of Organic Chemistry, 2014, v. 2014, n. 29, p. 6481, doi. 10.1002/ejoc.201402850
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- Article
Synthesis of Oxa-B-Ring Analogs of Colchicine through Rh-Catalyzed Intramolecular [5+2] Cycloaddition.
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- European Journal of Organic Chemistry, 2012, v. 2012, n. 24, p. 4501, doi. 10.1002/ejoc.201200677
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- Article
Synthesis and First Biological Evaluation of an Iron-Containing HETE Analogue.
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- European Journal of Organic Chemistry, 2011, v. 2011, n. 6, p. 1133, doi. 10.1002/ejoc.201001445
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- Article
Severe adverse events during sirolimus "off‐label" therapy for vascular anomalies.
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- Pediatric Blood & Cancer, 2021, v. 68, n. 8, p. 1, doi. 10.1002/pbc.28936
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- Article
Sickle cell disease in Germany: Results from a national registry.
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- 2020
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- Publication type:
- journal article
Effects of a 6-Month, Group-Based, Therapeutic Exercise Program for Childhood Cancer Outpatients on Motor Performance, Level of Activity, and Quality of Life.
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- 2016
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- Publication type:
- journal article
Organoarsenic Compounds with In Vitro Activity against the Malaria Parasite Plasmodium falciparum.
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- Biomedicines, 2020, v. 8, n. 8, p. 260, doi. 10.3390/biomedicines8080260
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- Article
Iridium(III) Complexes of Terpyridine- and Terpyridine-Analogous Ligands Bearing Sugar Residues and Their in vitro Activity.
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- European Journal of Inorganic Chemistry, 2016, v. 2016, n. 21, p. 3480, doi. 10.1002/ejic.201600325
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- Article
Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity ( This work was supported by grants from the Deutsche Forschungsgemeinschaft (Schm 875/1 to H.G.S.), Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS-R01/02; to T.W. and A.P.), the Verein zur Förderung der Tagesklinik e.V. (to A.P. and T.W.), the Berliner Krebsgesellschaft e.V. (to T.W.), and the Fonds der Chemischen Industrie (to H.G.S.). The authors would like to thank Dr. P. T. Daniel for kindly providing BJAB cells and laboratory equipment. Technical assistance by A. Richter in the performance of cell assays is gratefully acknowledged. The authors would also thank Dr. J. Lex, Dr. H. Schmickler, and Dr. M. Schäfer for advanced X-ray crystallographic, NMR spectroscopic and mass spectrometric measurements. )
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- Angewandte Chemie International Edition, 2004, v. 43, n. 13, p. 1731, doi. 10.1002/anie.200353132
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- Article
Apoptosis-inducing activity of Helleborus niger in ALL and AML.
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- Pediatric Blood & Cancer, 2009, v. 52, n. 4, p. 464, doi. 10.1002/pbc.21905
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- Article
Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.
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- ChemMedChem, 2017, v. 12, n. 3, p. 214, doi. 10.1002/cmdc.201600557
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- Article
Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins.
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- ChemMedChem, 2013, v. 8, n. 2, p. 256, doi. 10.1002/cmdc.201200505
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- Publication type:
- Article
Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl-Substituted Phenanthroline Ligands.
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- ChemMedChem, 2011, v. 6, n. 3, p. 429, doi. 10.1002/cmdc.201000517
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- Publication type:
- Article
Azides Derived from Colchicine and their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug.
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- ChemMedChem, 2010, v. 5, n. 5, p. 661, doi. 10.1002/cmdc.201000063
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- Publication type:
- Article
Cytotoxic Rhodium(III) and Iridium(III) Polypyridyl Complexes: Structure-Activity Relationships, Antileukemic Activity, and Apoptosis Induction.
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- ChemMedChem, 2009, v. 4, n. 2, p. 177, doi. 10.1002/cmdc.200800311
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- Publication type:
- Article
(2,6-Dimethylphenyl)arsonic Acid Induces Apoptosis through the Mitochondrial Pathway, Downregulates XIAP, and Overcomes Multidrug Resistance to Cytostatic Drugs in Leukemia and Lymphoma Cells In Vitro.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4713, doi. 10.3390/ijms25094713
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- Article
A Chemical-Biological Evaluation of Rhodium(I) N-Heterocyclic Carbene Complexes as Prospective Anticancer Drugs.
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- Chemistry - A European Journal, 2013, v. 19, n. 52, p. 17871, doi. 10.1002/chem.201302819
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- Article
Nucleoside Analogues with a 1,3-DieneFe(CO)<sub>3</sub> Substructure: Stereoselective Synthesis, Configurational Assignment, and Apoptosis-Inducing Activity.
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- Chemistry - A European Journal, 2013, v. 19, n. 39, p. 13017, doi. 10.1002/chem.201301672
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- Article
Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity.
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- Chemistry - A European Journal, 2012, v. 18, n. 38, p. 12096, doi. 10.1002/chem.201200083
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- Article
Mitochondrial Mode of Action of a Thymidine-Based Cisplatin Analogue Breaks Resistance in Cancer Cells.
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- Chemistry - A European Journal, 2010, v. 16, n. 48, p. 14498, doi. 10.1002/chem.201000785
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- Publication type:
- Article
KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri.
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- Journal of Biological Inorganic Chemistry (JBIC), 2021, v. 26, n. 8, p. 897, doi. 10.1007/s00775-021-01900-9
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- Article
Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts.
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- Journal of Biological Inorganic Chemistry (JBIC), 2012, v. 17, n. 4, p. 631, doi. 10.1007/s00775-012-0883-2
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- Article
The rare-earth yttrium complex [YR(mtbmp)(thf)] triggers apoptosis via the extrinsic pathway and overcomes multiple drug resistance in leukemic cells.
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- Medical Oncology, 2012, v. 29, n. 1, p. 235, doi. 10.1007/s12032-010-9787-6
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- Article