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- Title
VISOKODOZNA TERAPIJA PRAĆENA AUTOLOGNOM TRANSPLANTACIJOM MOŽE DOVESTI DO IZLIJEČENJA U 50 % BOLESNIKA S RELAPSNIM ILI REFRAKTORNIM HODGKINOVIM LIMFOMOM - ISKUSTVO JEDNOG CENTRA.
- Authors
MILUNOVIĆ, VIBOR; PATEKAR, MARTINA BOGELJIĆ; ZAGORAC, NIKOLA; PERICA, DRAŽEN; ROGULJ, INGA MANDAC; KARDUM-SKELIN, IKA; PLANINC-PERAICA, ANA; KOLONIĆ, SLOBODANKA OSTOJIĆ
- Abstract
The main aim of this study was to present outcomes and prognostic factors in relapsed and refractory classical Hodgkin lymphoma undergoing salvage chemotherapy followed by stem cell transplantation. This retrospective study included 101 adult patients being treated at a single center in the period between 1995-2014. The most commonly used salvage chemotherapy was miniBEAM. All patients received BEAM myeloablative protocol followed by stem cell reinfusion. The ORR was 92.1%. After a median of follow-up of 42 months, 5-year OS rate was 56% with 5-year PFS rate being 51%. In each survival curve, a plateau was achieved implying the curative possibility of autologous stem cell transplantation. Adverse prognostic factors associated with worse OS were presence of B symptoms and anemia at relapse and chemoresistance to salvage chemotherapy, defined as inability to achieve 2nd complete remission. However, in survival curve a plateau was reached indicating that 40% of chemorefractory patients can be cured with this approach. Only prognostic factor associated with inferior PFS was chemoresistance to salvage therapy. Outcomes for patients not responding to or relapsing after stem cell transplantation were less advantageous with 31% and 16% 5-years OS rates, stressing the need for better clinical approach in this subpopulation. Based on our results and according to the literature review, we demonstrate that salvage therapy followed by autologous stem cell transplantation represents a treatment of choice in transplant-eligible patients suffering from relapsed or refractory Hodgkin lymphoma.
- Publication
Acta Medica Croatica, 2017, Vol 71, Issue 1, p39
- ISSN
1330-0164
- Publication type
Article