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- Title
A resveratrol analog termed 3,3′,4,4′,5,5′-hexahydroxy- trans-stilbene is a potent HIV-1 inhibitor.
- Authors
Han, Ying‐Shan; Quashie, Peter K.; Mesplède, Thibault; Xu, Hongtao; Quan, Yudong; Jaeger, Walter; Szekeres, Thomas; Wainberg, Mark A.
- Abstract
HIV resistance to current anti-HIV drugs and drug toxicity have created a need for new anti-HIV agents. We have examined and characterized a synthetic resveratrol analog, termed 3,3′,4,4′,5,5′-hexahydroxy- trans-stilbene (M8), for potential anti-HIV activity. Here, we demonstrate that M8 possesses potent anti-HIV activity against several HIV variants with EC50 values in the low μM range. M8 was shown to act at a very early step of HIV entry prior to fusion to host cells. These results demonstrate that this novel resveratrol derivative possesses potent anti-HIV-1 activity and may have a mechanism of action that is different from current anti-HIV-1 drugs including entry inhibitors. Further structure-guided design might lead to the development of newer improved resveratrol derivatives that could have value either in therapy or as microbicides to prevent the sexual transmission of HIV-1. J. Med. Virol. 87:2054-2060, 2015. © 2015 Wiley Periodicals, Inc.
- Publication
Journal of Medical Virology, 2015, Vol 87, Issue 12, p2054
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.24271