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- Title
Effect of an acute increase in PCO2 on splanchnic perfusion and metabolism.
- Authors
Kiefer, Peter; Nunes, Sylvia; Kosonen, Petteri; Takala, Jukka; Kiefer, P; Nunes, S; Kosonen, P; Takala, J
- Abstract
<bold>Objectives: </bold>To evaluate the acute effects of an increase in PCO2 on splanchnic tissue perfusion and metabolism.<bold>Design: </bold>Clinical prospective study in the intensive care unit in a university clinic.<bold>Patients: </bold>Six patients with severe acute lung injury requiring mechanical ventilation. All patients had bilateral infiltrates on chest radiography, a PaO2/FIO2 ratio less than 200 mmHg, and stable hemodynamics without vasoactive drugs.<bold>Interventions: </bold>PCO2 was increased 5-20% by an added dead space from baseline, followed by a return to baseline.<bold>Measurements and Results: </bold>Splanchnic blood flow was measured using primed continuous infusion of indocyanine green dye with hepatic venous sampling and systemic hemodynamics by routine monitoring; we also determined the gastric mucosal-arterial PCO2 difference and splanchnic lactate/pyruvate exchange. PCO2 was increased by an added dead space; after 60 min all measurements were repeated; after return to baseline a third measurement followed. The increase in PCO2 had no significant effect on splanchnic blood flow or indices of perfusion and metabolism.<bold>Conclusion: </bold>Our results suggest that acute moderate changes in PCO2 have no major effect on splanchnic perfusion and metabolism.
- Subjects
HEMODYNAMICS; BLOOD circulation; METABOLISM; BLOOD; BLOOD flow; HOSPITAL wards
- Publication
Intensive Care Medicine, 2001, Vol 27, Issue 4, p775
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s001340100898