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- Title
Accuracy of a Rapid Multiplex Polymerase Chain Reaction Plus a Chromogenic Phenotypic Test Algorithm for Detection of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Gram-Negative Bacilli in Positive Blood Culture Bottles.
- Authors
Ong, Sean Wei Xiang; Hon, Pei Yun; Wee, Sharon Syn Hui; Chia, Jonathan Wei Zhong; Mendis, Shehara; Izharuddin, Ezlyn; Lin, Ray Junhao; Chia, Po Ying; Sim, Rees Chin Swee; Chen, Mark I-Cheng; Chow, Angela; Yoong, Joanne; Lye, David Chien; Teng, Christine B; Tambyah, Paul Anantharajah; Banerjee, Ritu; Patel, Robin; De, Partha Pratim; Vasoo, Shawn
- Abstract
We studied the performance of an algorithm combining multiplex polymerase chain reaction with phenotypic detection of extended-spectrum β-lactamases and carbapenemases directly from positive blood culture bottles in patients with gram-negative bacteremia and found good concordance with routine cultures. Such an algorithm may be a tool to improve time to optimal therapy in patients with gram-negative bacteremia.
- Subjects
CHROMOGENIC compounds; GRAM-negative bacteria; CARBAPENEM-resistant bacteria; BETA lactamases; POLYMERASE chain reaction; BLOOD testing; GRAM-negative bacterial diseases; DRUG resistance in microorganisms; PHENOTYPES; ALGORITHMS; MICROBIAL sensitivity tests
- Publication
Clinical Infectious Diseases, 2022, Vol 74, Issue 10, p1850
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab848