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- Title
Mutation L437P in the 2B domain of keratin 1 causes diffuse palmoplantar keratoderma in a Chinese pedigree.
- Authors
Liu, X. P.; Ling, J.; Xiong, H.; Shi, X. L.; Sun, X.; Pan, Q.; Hu, Z. M.; Wu, L. Q.; Liang, D. S.; Long, Z. G.; Dai, H. P.; Xia, J. H.; Xia, K.
- Abstract
Diffuse palmoplantar keratoderma (DPPK) is an autosomal dominant genodermatosis characterized by uniform hyperkeratosis of the palm and sole epidermis. This disorder can be caused by mutations in the genes keratin 1, keratin 9, keratin 16, desmoglein 1 and plakoglobin. Here we present a DPPK Chinese pedigree and identify the aetiology as a novel missense mutation, L437P, located in a highly conserved helix motif in domain 2B of KRT1. Functional analysis shows that overexpression of the L437P mutant in cultured cells leads to abnormal intermediate filament networks and filament aggregation. This gain-of-function mutation highlights the role of domain 2B in mediating filament assembly. Conflicts of interest The authors declare that they have no actual or potential conflicts of interest to disclose. Appropriate approval and procedures were used concerning human subjects.
- Subjects
KERATOSIS; SKIN diseases; KERATIN; EPIDERMAL diseases; GENETIC mutation; ETIOLOGY of diseases; DERMATOLOGY; MEDICAL research
- Publication
Journal of the European Academy of Dermatology & Venereology, 2009, Vol 23, Issue 9, p1079
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2009.03175.x