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- Title
The Role of the Agouti-Related Protein in Energy Balance Regulation.
- Authors
Ilnytska, O.; Argyropoulos, G.
- Abstract
The Agouti-Related Protein (AgRP) is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally. AgRP-deficiency, on the other hand, leads to increased metabolic rate and a longer lifespan when mice consume a high fat diet. In humans, AgRP polymorphisms have been consistently associated with resistance to fatness in Blacks and Whites and resistance to the development of type-2 diabetes in African Blacks. Systemically administered AgRP accumulates in the liver, the adrenal gland and fat tissue while recent findings suggest that AgRP may also have inverse agonist effects, both centrally and peripherally. AgRP could thus modulate energy balance via different actions. Its absence or reduced functionality may offer a benefit both in terms of bringing about negative energy balance in obesigenic environments, as well as leading to an increased lifespan.
- Subjects
PROTEINS; BIOENERGETICS; AGOUTI (Genus); HYPOTHALAMUS; ADRENAL glands
- Publication
Cellular & Molecular Life Sciences, 2008, Vol 65, Issue 17, p2721
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-008-8104-4